Recombinant human CRHBP protein

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. Recombinant human CRHBP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Corticotropin-releasing factor-binding protein precursor, corticotropin-releasing factor-binding protein precursor, CRF-BP, CRFBP

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

36.1 kDa (324aa)

Additionnal Information

CRHBP, corticotropin-releasing factor-binding protein precursor, corticotropin-releasing factor-binding protein precursor, CRF-BP, CRFBP, ATGP2557-10 µg, ATGP2557-20 µg, ATGP2557-50 µg, ATGP2557-100 µg, ATGP2557-250 µg, ATGP2557-500 µg, ATGP2557-1 mg, ATGP2557-10, ATGP2557-20, ATGP2557-50, ATGP2557-100, ATGP2557-250, ATGP2557-500, ATGP2557-1

References & Citations

Behan DP. et al. (1993) Genomics. 16:63-68.; ; Westphal NJ. et al. (2006) Front. Biosc.. 11: 1878-91.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Signal Transduction

NCBI Accession Number

NP_001873

Uniprot Accession Number

P24387

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSESRYLEL REAADYDPFL LFSANLKREL AGEQPYRRAL RCLDMLSLQG QFTFTADRPQ LHCAAFFISE PEEFITIHYD QVSIDCQGGD FLKVFDGWIL KGEKFPSSQD HPLPSAERYI DFCESGLSRR SIRSSQNVAM IFFRVHEPGN GFTLTIKTDP NLFPCNVISQ TPNGKFTLVV PHQHRNCSFS IIYPVVIKIS DLTLGHVNGL QLKKSSAGCE GIGDFVELLG GTGLDPSKMT PLADLCYPFH GPAQMKVGCD NTVVRMVSSG KHVNRVTFEY RQLEPYELEN PNGNSIGEFC LSGL