Recombinant human MMP-8 protein
MMP8 protein of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. MMP8 is part of a cluster of MMP. Recombinant human MMP8 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Neutrophil collagenase preproprotein, CLG1, HNC, MMP-8, PMNL-CL, Matrix metalloproteinase-8, MMP-8, PMNL collagenase
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
44.3 kDa (390aa)
Additionnal Information
References & Citations
Hasty K.A., et al (1990) . J. Biol. Chem. 265:11421-11424; ; Betz M., et al (1997) . Eur. J. Biochem. 247:356-363;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Cancer
NCBI Accession Number
NP_002415.1
Uniprot Accession Number
P22894
Species
Human
AA Sequence
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human DPYSL3/Dihydropyrimidinase-related protein 3 ELISA Kit
