Recombinant human MMP-1 protein

MMP1 protein of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3. Recombinant human MMP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Interstitial collagenase isoform 1 preproprotein, interstitial collagenase isoform 1 preproprotein, CLG, CLGN

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

45.0 kDa (393aa)

Additionnal Information

MMP1, interstitial collagenase isoform 1 preproprotein, interstitial collagenase isoform 1 preproprotein, CLG, CLGN, ATGP2542-10 µg, ATGP2542-20 µg, ATGP2542-50 µg, ATGP2542-100 µg, ATGP2542-250 µg, ATGP2542-500 µg, ATGP2542-1 mg, ATGP2542-10, ATGP2542-20, ATGP2542-50, ATGP2542-100, ATGP2542-250, ATGP2542-500, ATGP2542-1

References & Citations

Desrochers P.E., et al (1991) . J. Clin. Invest. 87:2258-2265; ; Templeton N.S., et al (1990) . Cancer Res. 50:5431-5437;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Scientific Category

Cancer

NCBI Accession Number

NP_002412

Uniprot Accession Number

P03956

Species

Human

AA Sequence

FVLTEGN PRWEQTHLTY RIENYTPDLP RADVDHAIEK AFQLWSNVTP LTFTKVSEGQ ADIMISFVRG DHRDNSPFDG PGGNLAHAFQ PGPGIGGDAH FDEDERWTNN FREYNLHRVA AHELGHSLGL SHSTDIGALM YPSYTFSGDV QLAQDDIDGI QAIYGRSQNP VQPIGPQTPK ACDSKLTFDA ITTIRGEVMF FKDRFYMRTN PFYPEVELNF ISVFWPQLPN GLEAAYEFAD RDEVRFFKGN KYWAVQGQNV LHGYPKDIYS SFGFPRTVKH IDAALSEENT GKTYFFVANK YWRYDEYKRS MDPGYPKMIA HDFPGIGHKV DAVFMKDGFF YFFHGTRQYK FDPKTKRILT LQKANSWFNC RKN