Recombinant human MMP-1 protein
MMP1 protein of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3. Recombinant human MMP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Interstitial collagenase isoform 1 preproprotein, interstitial collagenase isoform 1 preproprotein, CLG, CLGN
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
45.0 kDa (393aa)
Additionnal Information
References & Citations
Desrochers P.E., et al (1991) . J. Clin. Invest. 87:2258-2265; ; Templeton N.S., et al (1990) . Cancer Res. 50:5431-5437;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Cancer
NCBI Accession Number
NP_002412
Uniprot Accession Number
P03956
Species
Human
AA Sequence
Frequently Asked Questions
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