Recombinant human Complement Factor B protein
CFB is complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Recombinant human CFB protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Complement factor B preproprotein, AHuS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
28.4 kDa (257aa)
Additionnal Information
References & Citations
Mejia J.E., et al (1994) . Hum. Immunol. 39:49-53; ; Schwaeble W., et al (1993) . Immunobiology 188:221-232;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Immunology
NCBI Accession Number
NP_001701
Uniprot Accession Number
P00751
Species
Human
AA Sequence
Frequently Asked Questions
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