Recombinant human CD8 beta protein
CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Recombinant human CD8B protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEu2, LY3, LYT3, P37
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
19.2 kDa (172aa)
Additionnal Information
References & Citations
Heigele, A, et al. (2012) J. Virol. 86 (1), 36-48; ; Laugel, B., et al. (2011) J. Leukoc. Biol. 90 (6), 1089-1099;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing, 0.4M Urea, 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_004922
Uniprot Accession Number
P10966
Species
Human
AA Sequence
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