Recombinant human BRMS1 protein
BRMS1 reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC) . The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. Recombinant human BRMS1 protein, fused to T7-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Breast cancer metastasis suppressor 1 isoform 1, Breast cancer metastasis suppressor 1, DKFZp564A063
Expression System
E.coli
Antigen Species
Human
Tag
T7-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
29.9 kDa (261aa)
Additionnal Information
References & Citations
Meehan W.J., et al. (2004) J. Biol. Chem. 279:1562-1569.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_056214.1
Uniprot Accession Number
Q9HCU9
Species
Human
AA Sequence
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