Recombinant human NKp44/NCR2 protein
NCR2 belongs to the natural cytotoxicity receptor (NCR) family and contains 1 Ig-like (immunoglobulin-like) domain. This protein interacts with TYROBP/DAP12 and is selectively expressed by activated NK cells and by in vitro cultured (i. e. activated) TCRg/d lymphoid cells. NCR2 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Recombinant human NKP44 protein, fused to His-tag at N-terminus, was expressed in E. coli
Product Specifications
Product Name Alternative
Natural cytotoxicity triggering receptor 2 isoform 1, CD336, LY95, NK-p44 NKP44
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
15 kDa (133aa)
Additionnal Information
References & Citations
Vitale M, Bottino C et al. (1998) J Exp Med. 15; ;187 (12) :2065-72.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Signal Transduction
NCBI Accession Number
NP_004819.2
Uniprot Accession Number
O95944
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSQAQSKAQV LQSVAGQTLT VRCQYPPTGS LYEKKGWCKE ASALVCIRLV TSSKPRTMAW TSRFTIWDDP DAGFFTVTMT DLREEDSGHY WCRIYRPSDN SVSKSVRFYL VVS
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