Recombinant human JAK2 protein

JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. Recombinant human Jak2 protein, fused to His-tag at N-terminus, was expressed in E. coli

Product Specifications

Product Name Alternative

Janus kinase 2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), JTK10

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

18.1 kDa (157aa)

Additionnal Information

JAK2, Janus kinase 2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), JTK10, ATGP2487-10 µg, ATGP2487-20 µg, ATGP2487-50 µg, ATGP2487-100 µg, ATGP2487-250 µg, ATGP2487-500 µg, ATGP2487-1 mg, ATGP2487-10, ATGP2487-20, ATGP2487-50, ATGP2487-100, ATGP2487-250, ATGP2487-500, ATGP2487-1

References & Citations

Bole-Feysot C, Goffin V, . et al. (1998) . Endocr. Rev. 19 (3) : 225-68. doi:10.1210/er.19.3.225

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing , 10% glycerol, 0.4M urea

Scientific Category

Cancer

NCBI Accession Number

NP_004963

Uniprot Accession Number

O60674

Species

Human

AA Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE SPIFWYAPES LTESKFSVAS DVWSFGVVLY ELFTYIEKSK SPPAEFMRMI GNDKQGQMIV FHLIELLKNN GRLPRPDGCP DEIYMIMTEC WNNNVNQRPS FRDLALRVDQ IRDNMAG