Recombinant human JAK2 protein
JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. Recombinant human Jak2 protein, fused to His-tag at N-terminus, was expressed in E. coli
Product Specifications
Product Name Alternative
Janus kinase 2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), JTK10
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
18.1 kDa (157aa)
Additionnal Information
References & Citations
Bole-Feysot C, Goffin V, . et al. (1998) . Endocr. Rev. 19 (3) : 225-68. doi:10.1210/er.19.3.225
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing , 10% glycerol, 0.4M urea
Scientific Category
Cancer
NCBI Accession Number
NP_004963
Uniprot Accession Number
O60674
Species
Human
AA Sequence
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