Recombinant human IGFBP-rp1/IGFBP-7 protein
IGFBP7 is a member of the insulin-like growth factor (IGF) -binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm Recombinant human IGFBP7 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
28.8 kDa (279aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Akaogi K., et al (1994) . Biochem. Biophys. Res. Commun. 198:1046-1053; ; Oh Y., et al (1996) . J. Biol. Chem. 271:30322-30325;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT, 1mM EDTA
Scientific Category
Cancer
NCBI Accession Number
NP_001544
Uniprot Accession Number
Q16270
Species
Human
AA Sequence
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