Recombinant human B7-H4 protein

The VCTN1 is a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human VTCN1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

V-set domain containing T cell activation inhibitor 1, B7-H4, B7h.5, B7H4, B7S1, B7X, PRO1291, RP11-229A19.4, VCTN1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

28.2 kDa (258aa)

Additionnal Information

B7-H4, V-set domain containing T cell activation inhibitor 1, B7-H4, B7h.5, B7H4, B7S1, B7X, PRO1291, RP11-229A19.4, VCTN1, ATGP2478-10 µg, ATGP2478-20 µg, ATGP2478-50 µg, ATGP2478-100 µg, ATGP2478-250 µg, ATGP2478-500 µg, ATGP2478-1 mg, ATGP2478-10, ATGP2478-20, ATGP2478-50, ATGP2478-100, ATGP2478-250, ATGP2478-500, ATGP2478-1

References & Citations

Fauci, J.M., et al. (2012) Gynecol. Oncol. 127 (2), 420-425; ; Galazka, K., et al. (2012) Am. J. Reprod. Immunol. 68 (1), 85-93;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_078902

Uniprot Accession Number

Q7Z7D3

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSLIIGFGI SGRHSITVTT VASAGNIGED GILSCTFEPD IKLSDIVIQW LKEGVLGLVH EFKEGKDELS EQDEMFRGRT AVFADQVIVG NASLRLKNVQ LTDAGTYKCY IITSKGKGNA NLEYKTGAFS MPEVNVDYNA SSETLRCEAP RWFPQPTVVW ASQVDQGANF SEVSNTSFEL NSENVTMKVV SVLYNVTINN TYSCMIENDI AKATGDIKVT ESEIKRRSHL QLLNSKAS