Recombinant human Apolipoprotein A5/APOA5 protein
APOA5 is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. Recombinant human APOA5 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Apolipoprotein A-V precursor, Apolipoprotein A-V, APOAV, RAP3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
41.3 kDa (366aa)
Additionnal Information
References & Citations
Weinberg R.B., et al. (2003) J. Biol. Chem. 278:34438-34444.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing , 10% glycerol, 0.4M urea
Scientific Category
Metabolism
NCBI Accession Number
NP_443200
Uniprot Accession Number
Q6Q788
Species
Human
AA Sequence
Frequently Asked Questions
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