Recombinant human NSDHL protein
NSDHL, as known as Sterol-4-alpha-carboxylate 3-dehydrogenase, is involved in the production (synthesis) of cholesterol. During cholesterol synthesis, it participates in one of several steps that convert a molecule called lanosterol to cholesterol. Specifically, this enzyme removes a carbon atom and three hydrogen atoms (a methyl group) in the conversion of lanosterol to cholesterol. It is also an important component of cell membranes and myelin, the fatty covering that insulates nerve cells. Recombinant human NSDHL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Sterol-4-alpha-carboxylate 3-dehydrogenase decarboxylating, Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating, H105E3, SDR31E1, XAP104
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
35.5 kDa (320aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Morimoto M. et al. (2012) J Mol Histol. 43:95-106; ; McLarren KW. et al. (2010) Am J Hum Genet 87:905-914.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl
Scientific Category
Metabolism
NCBI Accession Number
NP_057006
Uniprot Accession Number
Q15738
Species
Human
AA Sequence
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