Recombinant human HVEM/TNFRSF14 protein

TNFRSF14, as known as herpesvirus entry mediator (HVEM), is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Recombinant human TNFRSF14 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, Tumor necrosis factor receptor-like 2, TR2, CD270, HVEM, ATAR, LIGHTR

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

19.7 kDa (187aa) confirmed by MALDI-TOF

Additionnal Information

HVEM, TNFRSF14, Tumor necrosis factor receptor superfamily member 14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, ATGP2443-10 µg, ATGP2443-20 µg, ATGP2443-50 µg, ATGP2443-100 µg, ATGP2443-250 µg, ATGP2443-500 µg, ATGP2443-1 mg, ATGP2443-10, ATGP2443-20, ATGP2443-50, ATGP2443-100, ATGP2443-250, ATGP2443-500, ATGP2443-1

References & Citations

Montgomery RI. et al. (1996) Cell. 87:427-436.; ; Kwon BS. et al. (1997) J Biol Chem. 272:14272-14276.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl

Scientific Category

Cancer

NCBI Accession Number

NP_003811

Uniprot Accession Number

Q92956

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSLPSCKED EYPVGSECCP KCSPGYRVKE ACGELTGTVC EPCPPGTYIA HLNGLSKCLQ CQMCDPAMGL RASRNCSRTE NAVCGCSPGH FCIVQDGDHC AACRAYATSS PGQRVQKGGT ESQDTLCQNC PPGTFSPNGT LEECQHQTKC SWLVTKAGAG TSSSHWV