Recombinant human EVI-1 protein

MDS1 is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. Recombinant human MDS1 protein, fused to His-tag at N-terminus, was expressed in E. coli

Product Specifications

Product Name Alternative

MDS1 and EVI1 complex locus, myelodysplasia syndrome 1, ecotropic viral integration site 1, MDS1, EVI1, PRDM3, MDS1-EVI1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

21.1 kDa (192aa)

Additionnal Information

PRDM3, Myelodysplasia syndrome protein 1, Myelodysplasia syndrome 1, MRI, Modulator of retrovirus infection homolog, MDS1-EVI1, MDS1 EVI1, MDS1 and EVI1 complex locus, MDS1, EVI1, Ecotropic viral integration site 1, Cell cycle regulator of non-homologous end joining, Cell cycle regulator of non homologous end joining, C7orf49, ATGP2426-10 µg, ATGP2426-20 µg, ATGP2426-50 µg, ATGP2426-100 µg, ATGP2426-250 µg, ATGP2426-500 µg, ATGP2426-1 mg, ATGP2426-010, ATGP2426-020, ATGP2426-050, ATGP2426-100, ATGP2426-250, ATGP2426-500, ATGP2426-01M

References & Citations

Fears S., et al. (1996) Proc. Natl. Acad. Sci. u.S.A. 93:1642-1647.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing , 10% glycerol, 0.4M urea

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_004982.1

Uniprot Accession Number

Q03112

Species

Human

AA Sequence

MRSKGRA RKLATNNECV YGNYPEIPLE EMPDADGVAS TPSLNIQEPC SPATSSEAFT PKEGSPYKAP IYIPDDIPIP AEFELRESNM PGAGLGIWTK RKIEVGEKFG PYVGEQRSNL KDPSYGWEVH LPRSRRVSVH SWLYLGKRSS DVGIAFSQAD VYMPGLQCAF LS