Recombinant human Vav-1 protein
Proto-oncogene vav isoform 1, also known as VAV1, is a member of the VAV gene family. The VAV1 proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. In addition, VAV1 contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of VAV1 is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages. Recombinant human VAV1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Proto-oncogene vav isoform 1, Proto-oncogene vav isoform 1, VAV, Proto-oncogene vav, vav 1 guanine nucleotide exchange factor, vav 1 oncogene
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
46.8 kDa (400aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Bustelo X R., et al. (1992) Nature. 356:68-71.; ; Katzav S., et al. (1989) EMBO J. 8:2283-2290.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol, 2mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_005419
Uniprot Accession Number
P15498
Species
Human
AA Sequence
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