Recombinant human DcR3/TNFRSF6B protein
TNFRSF6B belongs to Tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. This protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Recombinant human TNFRSF6B protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Tumor necrosis factor receptor superfamily member 6B, M68, TR6, DCR3, Decoy receptor 3, Decoy receptor for Fas ligand, DJ583P15.1.1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
32.1 kDa (294aa)
Additionnal Information
References & Citations
Pitti RM. et al. (1999) Nature. 396 : 699-703..; ; Yu KY. et al. (1999) J Biol Chem. 274: 13733-13736;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Immunology
NCBI Accession Number
NP_003814.1
Uniprot Accession Number
O95407
Species
Human
AA Sequence
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