Recombinant human DcR3/TNFRSF6B protein

TNFRSF6B belongs to Tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. This protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Recombinant human TNFRSF6B protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Tumor necrosis factor receptor superfamily member 6B, M68, TR6, DCR3, Decoy receptor 3, Decoy receptor for Fas ligand, DJ583P15.1.1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

32.1 kDa (294aa)

Additionnal Information

DcR3, TNFRSF6B, Tumor necrosis factor receptor superfamily member 6B, Tumor necrosis factor receptor superfamily member 6B, DCR3, DJ583P15.1.1, Decoy receptor 3, Decoy receptor for Fas ligand, M68, TR6, ATGP2416-10 µg, ATGP2416-20 µg, ATGP2416-50 µg, ATGP2416-100 µg, ATGP2416-250 µg, ATGP2416-500 µg, ATGP2416-1 mg, ATGP2416-10, ATGP2416-20, ATGP2416-50, ATGP2416-100, ATGP2416-250, ATGP2416-500, ATGP2416-1

References & Citations

Pitti RM. et al. (1999) Nature. 396 : 699-703..; ; Yu KY. et al. (1999) J Biol Chem. 274: 13733-13736;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Immunology

NCBI Accession Number

NP_003814.1

Uniprot Accession Number

O95407

Species

Human

AA Sequence

VAETPTY PWRDAETGER LVCAQCPPGT FVQRPCRRDS PTTCGPCPPR HYTQFWNYLE RCRYCNVLCG EREEEARACH ATHNRACRCR TGFFAHAGFC LEHASCPPGA GVIAPGTPSQ NTQCQPCPPG TFSASSSSSE QCQPHRNCTA LGLALNVPGS SSHDTLCTSC TGFPLSTRVP GAEECERAVI DFVAFQDISI KRLQRLLQAL EAPEGWGPTP RAGRAALQLK LRRRLTELLG AQDGALLVRL LQALRVARMP GLERSVRERF LPVH