Recombinant mouse RAPSN protein
43 kDa receptor-associated protein of the synapse, also known as RAPSN, is expressed in the postsynaptic membrane of skeletal muscle. RAPSN is required for the clustering of nicotinic acetylcholine receptors (nAChR) . It self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs) . RAPSN interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. This protein modifies trafficking of AChR within the cell. Overexpression inhibits agrin-induced AChR clustering pathway. Recombinant human RAPSN protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
43 kDa receptor-associated protein of the synapse, 43kDa, Nraps, Raps, rapsyn
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
48.8 kDa (435aa)
Additionnal Information
References & Citations
Maimone M M., et al. (1999) Mol Cell Neurosci. 14:340-354.; ; Han H., et al. (1999) J Neurocytol. 28:763-775;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Neuroscience
NCBI Accession Number
NP_033049
Uniprot Accession Number
P12672
Species
Mouse
AA Sequence
Frequently Asked Questions
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