Recombinant human TNFRSF27/EDA2R protein

EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA2R specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene. Recombinant human EDA2R protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Ectodysplasin A2 receptor, EDA-A2 receptor, EDAA2R, EDA-A2R, TNFRSF27, XEDAR, X-linked ectodysplasin-A2 receptor

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

17.7 kDa (161aa)

Additionnal Information

EDA2R, TNFRSF27, XEDAR, Ectodysplasin A2 receptor, Ectodysplasin A2 receptor, EDA-A2R, EDAA2R, TNFRSF27, XEDAR, ATGP2397-10 µg, ATGP2397-20 µg, ATGP2397-50 µg, ATGP2397-100 µg, ATGP2397-250 µg, ATGP2397-500 µg, ATGP2397-1 mg, ATGP2397-10, ATGP2397-20, ATGP2397-50, ATGP2397-100, ATGP2397-250, ATGP2397-500, ATGP2397-1

References & Citations

Sinha S.K., et al. (2002) J. Biol. Chem. 277:44953-44961; ; Yan M., et al. (2000) Science. 290:523-527;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Stem cell

NCBI Accession Number

NP_001229239

Uniprot Accession Number

Q9HAV5

Species

Human

AA Sequence

MDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ CAFQLSLVEA DAPTVPPQEA T