Recombinant human CHCHD3 protein
Coiled-coil-helix-coiled-coil-helix domain containing protein 3, also known as CHCHD3, is required for maintenance of mitochondrial crista integrity and mitochondrial function. This protein may act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. It has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Recombinant human CHCHD3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Coiled-coil-helix-coiled-coil-helix domain containing protein 3, MINOS3, PPP1R22
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
28.5 kDa (250aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Liu H., et al. (2012) PLoS ONE. 7:E34832-E34832; ; Alkhaja A.K., et al. (2012) Mol. Biol. Cell. 23:247-257;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_060282
Uniprot Accession Number
Q9NX63
Species
Human
AA Sequence
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