Recombinant human QKI protein

Protein quaking isoform HQK-5, also known as QKI, is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. It is involved in myelinization and oligodendrocyte differentiation, and it may play a role in schizophrenia. Defects or deletions in the QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Recombinant human QKI protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Protein quaking isoform HQK-5, Hqk, hqkI, QK, QK1, QK3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

40.1 kDa (364aa) confirmed by MALDI-TOF

Additionnal Information

QKI, Protein quaking isoform HQK-5, Hqk, hqkI, QK, QK1, QK3, ATGP2377-10 µg, ATGP2377-20 µg, ATGP2377-50 µg, ATGP2377-100 µg, ATGP2377-250 µg, ATGP2377-500 µg, ATGP2377-1 mg, ATGP2377-10, ATGP2377-20, ATGP2377-50, ATGP2377-100, ATGP2377-250, ATGP2377-500, ATGP2377-1

References & Citations

Hardy R J., et al. (1996) J Neurosci. 16: 7941-7949.; ; Ebersole T A., et al. (1996) Nat Genet. 12: 260-265.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_006766

Uniprot Accession Number

Q96PU8

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMVGEMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN