Recombinant human LSM5 protein
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. Recombinant human LSM5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
U6 snRNA-associated Sm-like protein LSm5 isoform a, LSM5 homolog, u6 small nuclear RNA associated (S.cerevisiae), YER146W
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.3 kDa (114aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Salgado-Garrido J., Bragado-Nilsson E. et al. (1999), EMBO J. 18:3451-3462
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.5) containing 10% glycerol, 0.15M NaCl, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_036454
Uniprot Accession Number
Q9Y4Y9
Species
Human
AA Sequence
MAANATT NPSQLLPLEL VDKCIGSRIH IVMKSDKEIV GTLLGFDDFV NMVLEDVTEF EITPEGRRIT KLDQILLNGN NITMLVPGGE GPEV
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