Recombinant human SIVA1 protein

Apoptosis regulatory protein Siva isoform 1, also known as SIVA1, is a death domain-containing proapoptotic protein identified as an intracellular ligand of CD27 and of the glucocorticoid-induced TNFR family-related gene, which are two members of the TNFR family expressed on lymphoid cells. SIVA1 expression is up-regulated in multiple pathological processes, little is known about the signaling pathway underlying the Siva-induced apoptosis. Recombinant human SIVA1 protein, fused to His-tag at N-terminus, was expressed in E. coli. (denatured)

Product Specifications

Product Name Alternative

Apoptosis regulatory protein Siva isoform 1, CD27BP, SIVA, Siva-1, Siva-2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

21.1 kDa (198aa)

Additionnal Information

SIVA1, Apoptosis regulatory protein Siva isoform 1, CD27BP, SIVA, Siva-1, Siva-2, ATGP2360-10 µg, ATGP2360-20 µg, ATGP2360-50 µg, ATGP2360-100 µg, ATGP2360-250 µg, ATGP2360-500 µg, ATGP2360-1 mg, ATGP2360-10, ATGP2360-20, ATGP2360-50, ATGP2360-100, ATGP2360-250, ATGP2360-500, ATGP2360-1

References & Citations

Py B., et al. (2004) J Immunol. 172:4008-4017.; ; Chu F., et al. (2004) Apoptosis. 9:83-95.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Scientific Category

Apoptosis

NCBI Accession Number

NP_006418

Uniprot Accession Number

O15304

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET