Recombinant human Epigen protein
EPGN is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein has been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. Recombinant human EPGN, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Epigen isoform 1 precursor, ALGV3072, EPG, PRO9904
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
12.1 kDa (111aa)
Additionnal Information
References & Citations
Kennedy, R.B., et al. (2012) Hum. Genet. 131 (9), 1403-1421; ; Wilson, K.J., et al. (2012) Growth Factors 30 (2), 107-116;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001257918
Uniprot Accession Number
Q6UW88
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSAAVTVTP PITAQQGNWT VNKTEADNIE GPIALKFSHL CLEDHNSYCI NGACAFHHEL EKAICRCFTG YTGERCEHLT LTSYAVDSYE K
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