Recombinant human Cathepsin Z protein

CTSZ is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined. Recombinant human CTSZ protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin P, Cathepsin X, Cathepsin Y, Cathepsin Z, Cathepsin Z preproprotein, Cathepsin Z1, CatX, CTSP, CTSX, CTSZ, Cysteine-type carboxypeptidase, Lysosomal carboxypeptidase B

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

29.5 kDa (265aa)

Additionnal Information

Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin P, Cathepsin X, Cathepsin X Z P, Cathepsin X, Z, P, Cathepsin X/Z/P, Cathepsin XZP, Cathepsin Y, Cathepsin Z, Cathepsin Z preproprotein, Cathepsin Z1, Cathepsin-IV, Cathepsin-X, Cathepsin-Y, Cathepsin-Z, Cathepsin-Z1, Cathepsin-B2, CatX, CTSP, CTSX, CTSZ, Cysteine-type carboxypeptidase, Lysosomal carboxypeptidase B, ATGP2328-10 µg, ATGP2328-20 µg, ATGP2328-50 µg, ATGP2328-100 µg, ATGP2328-250 µg, ATGP2328-500 µg, ATGP2328-1 mg, ATGP2328-010, ATGP2328-020, ATGP2328-050, ATGP2328-100, ATGP2328-250, ATGP2328-500, ATGP2328-01M

References & Citations

Santamaria I, . et al. (1998) . J Biol Chem 273 (27) : 16816-23.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Scientific Category

Cancer

NCBI Accession Number

NP_001327

Uniprot Accession Number

Q9UBR2

Species

Human

AA Sequence

LPKSWDW RNVDGVNYAS ITRNQHIPQY CGSCWAHAST SAMADRINIK RKGAWPSTLL SVQNVIDCGN AGSCEGGNDL SVWDYAHQHG IPDETCNNYQ AKDQECDKFN QCGTCNEFKE CHAIRNYTLW RVGDYGSLSG REKMMAEIYA NGPISCGIMA TERLANYTGG IYAEYQDTTY INHVVSVAGW GISDGTEYWI VRNSWGEPWG ERGWLRIVTS TYKDGKGARY NLAIEEHCTF GDPIV