Recombinant human SPRY4 protein
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS. Recombinant human SPRY4 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Protein sprouty homolog 4 isoform 2, Protein sprouty homolog 4 isoform 2, Sprouty homolog 4 (Drosophila)
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
34.9 kDa (322aa)
Additionnal Information
References & Citations
Katoh Y, Katoh M. (2006) . Int J Mol Med 17 (3) : 529-32
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001120968
Uniprot Accession Number
Q9C004
Species
Human
AA Sequence
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