Recombinant human DUSP26 protein

DuSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. This protein inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DuSP26 can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK) . Recombinant human DuSP26 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Dual specificity protein phosphatase 26, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, Neuroendocrine-associated phosphatase, DUSP24, LDP4, MKP8, NATA1, SKRP3, NEAP

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

26.3 kDa (234aa)

Additionnal Information

DuSP26, Dual specificity protein phosphatase 26, Dual specificity protein phosphatase 26, Dual specificity phosphatase 26 (putative), DuSP24, LDP-4, MKP8, NATA1, SKRP3, ATGP2324-10 µg, ATGP2324-20 µg, ATGP2324-50 µg, ATGP2324-100 µg, ATGP2324-250 µg, ATGP2324-500 µg, ATGP2324-1 mg, ATGP2324-10, ATGP2324-20, ATGP2324-50, ATGP2324-100, ATGP2324-250, ATGP2324-500, ATGP2324-1

References & Citations

Vasudevan S.A.. et al. (2005) . Biochem. Biophys. Res. Commun. 330:511-518; ; Yu W., et al. (2007) . Oncogene 26:1178-1187;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Scientific Category

Signal Transduction

NCBI Accession Number

NP_076930

Uniprot Accession Number

Q9BV47

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA