Recombinant human Fucosyltransferase 3/FUT3 protein

Fucosyltransferase 3, also known as FuT3, may catalyze alpha-1, 3 and alpha-1, 4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. This protein may be involved in blood group Lewis determination; Lewis-positive (Le+) individuals have an active enzyme while Lewis-negative (Le-) individuals have an inactive enzyme. Also acts on the corresponding 1, 4-galactosyl derivative, forming 1, 3-L-fucosyl links. Recombinant human FuT3 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, Alpha-3-fucosyltransferase FUT3, Blood group Lewis alpha-4-fucosyltransferase, Lewis FT, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FT3B, LE

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

40.6 kDa (350aa)

Additionnal Information

Fucosyltransferase3, FUT3, Fucosyltransferase 3, Fucosyltransferase 3, CD174, FT3B, FucT-III, LE, Les, ATGP2322-10 µg, ATGP2322-20 µg, ATGP2322-50 µg, ATGP2322-100 µg, ATGP2322-250 µg, ATGP2322-500 µg, ATGP2322-1 mg, ATGP2322-10, ATGP2322-20, ATGP2322-50, ATGP2322-100, ATGP2322-250, ATGP2322-500, ATGP2322-1

References & Citations

Cameron H.S., et al. (1995) J. Biol. Chem. 270:20112-20122; ; Nishihara S., et al. (1993) Biochem. Biophys. Res. Commun. 196:624-631;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_001091110

Uniprot Accession Number

P21217

Species

Human

AA Sequence

RVSRDDA TGSPRAPSGS SRQDTTPTRP TLLILLWTWP FHIPVALSRC SEMVPGTADC HITADRKVYP QADTVIVHHW DIMSNPKSRL PPSPRPQGQR WIWFNLEPPP NCQHLEALDR YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH PPLNLSAKTE LVAWAVSNWK PDSARVRYYQ SLQAHLKVDV YGRSHKPLPK GTMMETLSRY KFYLAFENSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD LARYLQELDK DHARYLSYFR WRETLRPRSF SWALDFCKAC WKLQQESRYQ TVRSIAAWFT

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