Recombinant human GIMAP5 protein
GIMAP5 is a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36. 1. GIMAP5 is an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. Recombinant human GIMAP5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
GTPase IMAP family member 5, GTPase IMAP family member 5, HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
34.4 kDa (307aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wong V.W., et al. (2010) Self/Nonself. 1:259-268; ; Ota T., et al. (2004) Nat. Genet. 36:40-45;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 2mM DTT
Scientific Category
Immunology
NCBI Accession Number
NP_060854
Uniprot Accession Number
Q96F15
Species
Human
AA Sequence
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