Recombinant human GIMAP5 protein

GIMAP5 is a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36. 1. GIMAP5 is an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. Recombinant human GIMAP5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

GTPase IMAP family member 5, GTPase IMAP family member 5, HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

34.4 kDa (307aa) confirmed by MALDI-TOF

Additionnal Information

GIMAP5, GTPase IMAP family member 5, GTPase IMAP family member 5, HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD, ATGP2319-10 µg, ATGP2319-20 µg, ATGP2319-50 µg, ATGP2319-100 µg, ATGP2319-250 µg, ATGP2319-500 µg, ATGP2319-1 mg, ATGP2319-10, ATGP2319-20, ATGP2319-50, ATGP2319-100, ATGP2319-250, ATGP2319-500, ATGP2319-1

References & Citations

Wong V.W., et al. (2010) Self/Nonself. 1:259-268; ; Ota T., et al. (2004) Nat. Genet. 36:40-45;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 2mM DTT

Scientific Category

Immunology

NCBI Accession Number

NP_060854

Uniprot Accession Number

Q96F15

Species

Human

AA Sequence

MGGFQRG KYGTMAEGRS EDNLSATPPA LRIILVGKTG CGKSATGNSI LGQPVFESKL RAQSVTRTCQ VKTGTWNGRK VLVVDTPSIF ESQADTQELY KNIGDCYLLS APGPHVLLLV IQLGRFTAQD TVAIRKVKEV FGTGAMRHVV ILFTHKEDLG GQALDDYVAN TDNCSLKDLV RECERRYCAF NNWGSVEEQR QQQAELLAVI ERLGREREGS FHSNDLFLDA QLLQRTGAGA CQEDYRQYQA KVEWQVEKHK QELRENESNW AYKALLRVKH LMLLHYE