Recombinant human CARD17 protein
CARD17 is a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. This protein inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, CARD17 do not induce NF-kappa-B activation. Recombinant human CARD17 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Caspase recruitment domain-containing protein 17, Caspase recruitment domain family, member 17, INCA
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
14.3 kDa (133aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Lamkanfi M., et al. (2004), Biol. Chem. 279:51729-51738
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Scientific Category
Apoptosis
NCBI Accession Number
NP_001007233
Uniprot Accession Number
Q5XLA6
Species
Human
AA Sequence
MADKVLK EKRKQFIRSV GEGTINGLLG ELLETRVLSQ EEIEIVKCEN ATVMDKARAL LDSVIRKGAP ACQICITYIC EEDSHLAGTL GLSAGPTSGN HLTTQDSQIV LPS
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Rhodopseudomonas palustris Molybdenum import ATP-binding protein ModC (modC)
Recombinant Rhodopseudomonas palustris Molybdenum import ATP-binding protein ModC (modC)
Recombinant Rhodopseudomonas palustris Molybdenum import ATP-binding protein ModC (modC)
Recombinant Rhodopseudomonas palustris Molybdenum import ATP-binding protein ModC (modC)
Recombinant Rhodopseudomonas palustris Molybdenum import ATP-binding protein ModC (modC)