Recombinant human ZNF346 protein

ZNF346 is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. ZNF346 may be involved in cell growth and survival. Recombinant human ZNF346 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Zinc finger protein 346, JAZ, Zfp346

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

35.3 kDa (317aa) confirmed by MALDI-TOF

Additionnal Information

ZNF346, Zinc finger protein 346, JAZ, Zfp346, ATGP2306-10 µg, ATGP2306-20 µg, ATGP2306-50 µg, ATGP2306-100 µg, ATGP2306-250 µg, ATGP2306-500 µg, ATGP2306-1 mg, ATGP2306-10, ATGP2306-20, ATGP2306-50, ATGP2306-100, ATGP2306-250, ATGP2306-500, ATGP2306-1

References & Citations

Schmitt J., et al. (2012) Int J Cancer. 131 (3) :673-82.; ; Yang M., et al. (1999) J Biol Chem. 274 (39) :27399-406.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_036411

Uniprot Accession Number

Q9UL40

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMEYPAPA TVQAADGGAA GPYSSSELLE GQEPDGVRFD RERARRLWEA VSGAQPVGRE EVEHMIQKNQ CLFTNTQCKV CCALLISESQ KLAHYQSKKH ANKVKRYLAI HGMETLKGET KKLDSDQKSS RSKDKNQCCP ICNMTFSSPV VAQSHYLGKT HAKNLKLKQQ STKVEALHQN REMIDPDKFC SLCHATFNDP VMAQQHYVGK KHRKQETKLK LMARYGRLAD PAVTDFPAGK GYPCKTCKIV LNSIEQYQAH VSGFKHKNQS PKTVASSLGQ IPMQRQPIQK DSTTLED