Recombinant human NFKBID protein

NF-kappa-B inhibitor delta, also known as NFKBID, is a member of the IkB family of proteins can be divided into four groups (IkB-alpha, IkB-beta, IkB-gamma, IkB-epsilon) . NFKBID plays a role in the regulation of both inflammatory responses and cytokine, IL-2 and IL-6 expression via NFkB activity. Existing as three alternatively spliced isoforms, NFKBID associates with RelB, NFkB p50 and NFkB p65 in nucleus, and is thought to assist in thymocyte selection in response to TCR induction. Recombinant human NFKBID protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

NF-kappa-B inhibitor delta, IkappaBNS, TA-NFKBH

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

35.9 kDa (336aa) confirmed by MALDI-TOF

Additionnal Information

NFKBID, NF-kappa-B inhibitor delta, IkappaBNS, TA-NFKBH, ATGP2305-10 µg, ATGP2305-20 µg, ATGP2305-50 µg, ATGP2305-100 µg, ATGP2305-250 µg, ATGP2305-500 µg, ATGP2305-1 mg, ATGP2305-10, ATGP2305-20, ATGP2305-50, ATGP2305-100, ATGP2305-250, ATGP2305-500, ATGP2305-1

References & Citations

Wand L., et al. (2000) Clin Cancer Res. 6:2988-2993.; ; Trowsdale J., et al. (2001) Immunol Rev. 181:20-38.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_640332.1

Uniprot Accession Number

Q8NI38

Species

Human

AA Sequence

MEAGPWR VSAPPSGPPQ FPAVVPGPSL EVARAHMLAL GPQQLLAQDE EGDTLLHLFA ARGLRWAAYA AAEVLQVYRR LDIREHKGKT PLLVAAAANQ PLIVEDLLNL GAEPNAADHQ GRSVLHVAAT YGLPGVLLAV LNSGVQVDLE ARDFEGLTPL HTAILALNVA MRPSDLCPRV LSTQARDRLD CVHMLLQMGA NHTSQEIKSN KTVLHLAVQA ANPTLVQLLL ELPRGDLRTF VNMKAHGNTA LHMAAALPPG PAQEAIVRHL LAAGADPTLR NLENEQPVHL LRPGPGPEGL RQLLKRSRVA PPGLSS