Recombinant human NFKBID protein
NF-kappa-B inhibitor delta, also known as NFKBID, is a member of the IkB family of proteins can be divided into four groups (IkB-alpha, IkB-beta, IkB-gamma, IkB-epsilon) . NFKBID plays a role in the regulation of both inflammatory responses and cytokine, IL-2 and IL-6 expression via NFkB activity. Existing as three alternatively spliced isoforms, NFKBID associates with RelB, NFkB p50 and NFkB p65 in nucleus, and is thought to assist in thymocyte selection in response to TCR induction. Recombinant human NFKBID protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
NF-kappa-B inhibitor delta, IkappaBNS, TA-NFKBH
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
35.9 kDa (336aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wand L., et al. (2000) Clin Cancer Res. 6:2988-2993.; ; Trowsdale J., et al. (2001) Immunol Rev. 181:20-38.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_640332.1
Uniprot Accession Number
Q8NI38
Species
Human
AA Sequence
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