Recombinant human NEURL2 protein
NEuRL2 plays an important role in the process of myofiber differentiation and maturation. This protein is probable substrate-recognition component of a SCF-like ECS (Elongin BC-CuL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. It probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, NEuRL2 controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma. Recombinant human NEuRL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Neuralized homolog 2, C20orf163, OZZ, Ozz-E3, Neuralized E3 ubiquitin protein ligase 2, Neuralized-like 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
34.1 kDa (308aa)
Additionnal Information
References & Citations
Aurino, S., et al. (2008) Acta Myol 27, 90-97; ; Song, R., et al. (2006) J. Biol. Chem. 281 (47), 36391-36400
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Scientific Category
Ubiquitination
NCBI Accession Number
NP_542787
Uniprot Accession Number
Q9BR09
Species
Human
AA Sequence
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