Recombinant human PP4 Catalytic Subunit protein

Serine/threonine-protein phosphatase 4 catalytic subunit, also known as PPP4C, belongs to the Serine/threonine-protein phosphatase catalytic subunits. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPP4C is a putative member of a novel PP family. The PPP4C may play a role in dephosphorylation and regulation of HDAC3. Recombinant human PPP4C protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Serine/threonine-protein phosphatase 4 catalytic subunit, PP4, PP4C, PPH3, PPP4, PPX

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

37.5 kDa (330aa)

Additionnal Information

PP4 Catalytic Subunit, Serine/threonine-protein phosphatase 4 catalytic subunit, PP4, PP4C, PPH3, PPP4, PPX, ATGP2288-10 µg, ATGP2288-20 µg, ATGP2288-50 µg, ATGP2288-100 µg, ATGP2288-250 µg, ATGP2288-500 µg, ATGP2288-1 mg, ATGP2288-10, ATGP2288-20, ATGP2288-50, ATGP2288-100, ATGP2288-250, ATGP2288-500, ATGP2288-1

References & Citations

Cohen P T., et al. (1993) Biochem Soc Trans. 21:884-888.; ; Mumby M C., et al. (1993) Phys Rev. 73:673-699.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_002711

Uniprot Accession Number

P60510

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAEISDL DRQIEQLRRC ELIKESEVKA LCAKAREILV EESNVQRVDS PVTVCGDIHG QFYDLKELFR VGGDVPETNY LFMGDFVDRG FYSVETFLLL LALKVRYPDR ITLIRGNHES RQITQVYGFY DECLRKYGSV TVWRYCTEIF DYLSLSAIID GKIFCVHGGL SPSIQTLDQI RTIDRKQEVP HDGPMCDLLW SDPEDTTGWG VSPRGAGYLF GSDVVAQFNA ANDIDMICRA HQLVMEGYKW HFNETVLTVW SAPNYCYRCG NVAAILELDE HLQKDFIIFE AAPQETRGIP SKKPVADYFL