Recombinant human DERP6/ELP5 protein

Elongator acetyltransferase complex subunit 5, also known as ELP5, acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. This protein is involved in cell migration. Recombinant human ELP5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Elongator acetyltransferase complex subunit 5, C17orf81, DERP6, HSPC002, MST071, MSTP071, Elongator complex protein 5, Dermal papilla derived protein 6, S-phase 2 protein

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

37.2 kDa (339aa) confirmed by MALDI-TOF

Additionnal Information

C17orf81, Dermal papilla derived protein 6, DERP6, Elongator acetyltransferase complex subunit 5, Elongator complex protein 5, ELP5, HSPC002, MST071, MSTP071, S-phase 2 protein, S phase 2 protein, ATGP2274-10 µg, ATGP2274-20 µg, ATGP2274-50 µg, ATGP2274-100 µg, ATGP2274-250 µg, ATGP2274-500 µg, ATGP2274-1 mg, ATGP2274-010, ATGP2274-020, ATGP2274-050, ATGP2274-100, ATGP2274-250, ATGP2274-500, ATGP2274-01M

References & Citations

Yuan J., et al. (2006) Mol. Biol. Rep. 33:151-158; ; Zhang Q.-H., et al. (2000) Genome Res. 10:1546-1560

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_056177

Uniprot Accession Number

Q8TE02

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMTPSEGA RAGTGRELEM LDSLLALGGL VLLRDSVEWE GRSLLKALVK KSALCGEQVH ILGCEVSEEE FREGFDSDIN NRLVYHDFFR DPLNWSKTEE AFPGGPLGAL RAMCKRTDPV PVTIALDSLS WLLLRLPCTT LCQVLHAVSH QDSCPGDSSS VGKVSVLGLL HEELHGPGPV GALSSLAQTE VTLGGTMGQA SAHILCRRPR QRPTDQTQWF SILPDFSLDL QEGPSVESQP YSDPHIPPVD PTTHLTFNLH LSKKEREARD SLILPFQFSS EKQQALLRPR PGQATSHIFY EPDAYDDLDQ EDPDDDLDI