Recombinant human Tmp21/p23 protein
TMED10 is a member of the EMP24/GP25L/p24 family and a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. Recombinant human TMED10 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Transmembrane emp24 domain-containing protein 10, p23, P24 (DELTA), S31I125, S31III125, Tmp-21-I, TMP21
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
20 kDa (177aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Chen F, Hasegawa H, et al. (2006) . Nature. 440 (7088) :1208-12.; ; Wang H, et al. (2002) . J Biol Chem. 277 (6) :4541-50.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_006818
Uniprot Accession Number
P49755
Species
Human
AA Sequence
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