Recombinant human Prohibitin 2 protein
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases by similarity. This protein functions as an estrogen receptor (ER) -selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging. Recombinant human PHB2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Prohibitin 2, Bap37, p22, B cell receptor associated protein 37, BAP, BCAP37, PNAS-141, REA, PHB2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
35.7 kDa (322aa)
Additionnal Information
References & Citations
Kategaya, L.S., et al. (2012) PLoS ONE 7 (2), E31987; ; Emerson, V., et al. (2010) J. Virol. 84 (3), 1355-1365
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001138303.1
Uniprot Accession Number
Q99623
Species
Human
AA Sequence
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