Recombinant human BEX1 protein

Brain expressed, X-linked 1, also known as BEX1, is signaling adapter molecule involved in p75NTR/NGFR signaling. This protein plays a role in cell cycle progression and neuronal differentiation. This protein inhibits neuronal differentiation in response to nerve growth factor (NGF) . It may act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Recombinant human BEX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Brain expressed X-linked 1, Brain expressed, X-linked 1, BEX2, HBEX2, HGR74-h

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by BCA assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

17.2 kDa (148aa) confirmed by MALDI-TOF

Additionnal Information

BEX1, Brain expressed X-linked 1, Brain expressed, X-linked 1, BEX2, HBEX2, HGR74-h, ATGP2178-10 µg, ATGP2178-20 µg, ATGP2178-50 µg, ATGP2178-100 µg, ATGP2178-250 µg, ATGP2178-500 µg, ATGP2178-1 mg, ATGP2178-10, ATGP2178-20, ATGP2178-50, ATGP2178-100, ATGP2178-250, ATGP2178-500, ATGP2178-1

References & Citations

Yang Q.-S., et al. (2002) Biochem. Genet. 40:1-12; ; Quentmeier H., et al. (2005) Leukemia. 19:1488-1489

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_060946

Uniprot Accession Number

Q9HBH7

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMESKEKR AVNSLSMENA NQENEEKEQV ANKGEPLALP LDAGEYCVPR GNRRRFRVRQ PILQYRWDMM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH HDEFCLMP