Recombinant human BEX1 protein
Brain expressed, X-linked 1, also known as BEX1, is signaling adapter molecule involved in p75NTR/NGFR signaling. This protein plays a role in cell cycle progression and neuronal differentiation. This protein inhibits neuronal differentiation in response to nerve growth factor (NGF) . It may act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Recombinant human BEX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Brain expressed X-linked 1, Brain expressed, X-linked 1, BEX2, HBEX2, HGR74-h
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by BCA assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
17.2 kDa (148aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yang Q.-S., et al. (2002) Biochem. Genet. 40:1-12; ; Quentmeier H., et al. (2005) Leukemia. 19:1488-1489
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_060946
Uniprot Accession Number
Q9HBH7
Species
Human
AA Sequence
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