Recombinant human KLF7 protein

KLF7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. Recombinant human KLF7 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Kruppel-like factor 7, uKLF

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

35.8 kDa (325aa)

Additionnal Information

KLF7, Kruppel-like factor 7, uKLF, ATGP2174-10 µg, ATGP2174-20 µg, ATGP2174-50 µg, ATGP2174-100 µg, ATGP2174-250 µg, ATGP2174-500 µg, ATGP2174-1 mg, ATGP2174-10, ATGP2174-20, ATGP2174-50, ATGP2174-100, ATGP2174-250, ATGP2174-500, ATGP2174-1

References & Citations

Matsumoto N., et al. (1998) J. Biol. Chem. 273:28229-28237; ; Kawamura Y., et al. (2006) Mol. Endocrinol. 20:844-856

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_003700

Uniprot Accession Number

O75840

Species

Human

AA Sequence

MDVLASY SIFQELQLVH DTGYFSALPS LEETWQQTCL ELERYLQTEP RRISETFGED LDCFLHASPP PCIEESFRRL DPLLLPVEAA ICEKSSAVDI LLSRDKLLSE TCLSLQPASS SLDSYTAVNQ AQLNAVTSLT PPSSPELSRH LVKTSQTLSA VDGTVTLKLV AKKAALSSVK VGGVATAAAA VTAAGAVKSG QSDSDQGGLG AEACPENKKR VHRCQFNGCR KVYTKSSHLK AHQRTHTGEK PYKCSWEGCE WRFARSDELT RHYRKHTGAK PFKCNHCDRC FSRSDHLALH MKRHI