Recombinant human ASPSCR1 protein
ASPSCR1 contains a uBX domain and interacts with glucose transporter type 4 (GLuT4) . This protein is a tether, which sequesters the GLuT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLuT4 to the plasma membrane within minutes of insulin stimulation. Translocation t (X;17) (p11; q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Recombinant human ASPSCR1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tether containing uBX domain for GLuT4 isoform 1, ASPCR1, ASPL, ASPS, RCC17, TuG, uBXD9, uBXN9
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
62.6 kDa (576aa)
Additionnal Information
References & Citations
Bogan JS, Hendon N, et al. (2003) . Nature. 425 (6959) :727-33.; ; Argani P, Antonescu CR, et al. (2001) . Am J Pathol. 159 (1) :179-92.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_076988.1
Uniprot Accession Number
Q9BZE9
Species
Human
AA Sequence
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