Recombinant human SCC-S2/TNFAIP8 protein

TNFAIP8 belongs to the TNFAIP8 family. This protein acts as a negative mediator of apoptosis and may play a role in tumor progression. It suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Recombinant human TNFAIP8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tumor necrosis factor alpha-induced protein 8, GG2-1; MDC-3.13, SCC-S2, SCCS2, TNF alpha induced protein 8, NF-kappa-B-inducible DED-containing protein, NDED

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

25 kDa (221aa) confirmed by MALDI-TOF

Additionnal Information

TNFAIP8, Tumor necrosis factor alpha-induced protein 8, GG2-1; MDC-3.13, SCC-S2, SCCS2, ATGP2150-10 µg, ATGP2150-20 µg, ATGP2150-50 µg, ATGP2150-100 µg, ATGP2150-250 µg, ATGP2150-500 µg, ATGP2150-1 mg, ATGP2150-10, ATGP2150-20, ATGP2150-50, ATGP2150-100, ATGP2150-250, ATGP2150-500, ATGP2150-1

References & Citations

Kumar D, Gokhale P, et al. (2004) . Oncogene. 23 (2) :612-6.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Scientific Category

Other

NCBI Accession Number

NP_055165

Uniprot Accession Number

O95379

Species

Human

AA Sequence

MHSEAEE SKEVATDVFN SKNLAVQAQK KILGKMVSKS IATTLIDDTS SEVLDELYRV TREYTQNKKE AEKIIKNLIK TVIKLAILYR NNQFNQDELA LMEKFKKKVH QLAMTVVSFH QVDYTFDRNV LSRLLNECRE MLHQIIQRHL TAKSHGRVNN VFDHFSDCEF LAALYNPFGN FKPHLQKLCD GINKMLDEEN I