Recombinant human C1D protein

Nuclear nucleic acid-binding protein C1D, also known as C1D, plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5. 8S rRNA; this function may include MPHOSPH6. This protein can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. This protein can induce apoptosis in a p53/TP53 dependent manner. Recombinant human C1D protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Nuclear nucleic acid-binding protein C1D, hC1D, LRP1, SuN-CoR, SuNCOR

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

18.4 kDa (164aa) confirmed by MALDI-TOF

Additionnal Information

C1D, Nuclear nucleic acid-binding protein C1D, hC1D, LRP1, SuN-CoR, SuNCOR, ATGP2147-10 µg, ATGP2147-20 µg, ATGP2147-50 µg, ATGP2147-100 µg, ATGP2147-250 µg, ATGP2147-500 µg, ATGP2147-1 mg, ATGP2147-10, ATGP2147-20, ATGP2147-50, ATGP2147-100, ATGP2147-250, ATGP2147-500, ATGP2147-1

References & Citations

Erdemir T., et al. (2002) J. Cell Sci. 115:207-216; ; Schilders G., et al. (2007) Nucleic Acids Res. 35:2564-2572

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_775269

Uniprot Accession Number

Q13901

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAGEEIN EDYPVEIHEY LSAFENSIGA VDEMLKTMMS VSRNELLQKL DPLEQAKVDL VSAYTLNSMF WVYLATQGVN PKEHPVKQEL ERIRVYMNRV KEITDKKKAG KLDRGAASRF VKNALWEPKS KNASKVANKG KSKS