Recombinant human FSBP protein

Fibrinogen silencer-binding protein, also known as FSBP, is interacts with X11alpha. X11alpha/FSBP complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. Recombinant human FSBP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Fibrinogen silencer-binding protein, Fibrinogen silencer binding protein

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

37.2 kDa (322aa)

Additionnal Information

FSBP, Fibrinogen silencer-binding protein, Fibrinogen silencer binding protein, ATGP2136-10 µg, ATGP2136-20 µg, ATGP2136-50 µg, ATGP2136-100 µg, ATGP2136-250 µg, ATGP2136-500 µg, ATGP2136-1 mg, ATGP2136-10, ATGP2136-20, ATGP2136-50, ATGP2136-100, ATGP2136-250, ATGP2136-500, ATGP2136-1

References & Citations

Lau KF., et al. (2010) Neuroreport. 21 (11) :761-6

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1M urea, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_001243070

Uniprot Accession Number

O95073

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMVGKARS SNFTLSEKLD LLKLVKPYVK ILEEHTNKHS VIVEKNRCWD IIAVNYNAIG VDRPPRTAQG LRTLYKRLKE YAKQELLQQK ETQSDFKSNI SEPTKKVMEM IPQISSFCLV RDRNHIQSAN LDEEAQAGTS SLQVMLDHHP VAITVEVKQE EDIKPPPPLV LNSQQSDTLE QREEHELVHV MERSLSPSLS SVDMRMTSSP SSIPRRDDFF RHESGEHFRS LLGYDPQILQ MLKEEHQIIL ENQKNFGLYV QEKRDGLKRR QQLEEELLRA KIEVEKLKAI RLRHDLPEYN SL