Recombinant human OSCAR protein

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. OSCAR is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human OSCAR protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Osteoclast-associated immunoglobulin-like receptor isoform 1, PIGR3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

31.2 kDa (291aa)

Additionnal Information

OSCAR, Osteoclast-associated immunoglobulin-like receptor isoform 1, PIGR3, ATGP2129-10 µg, ATGP2129-20 µg, ATGP2129-50 µg, ATGP2129-100 µg, ATGP2129-250 µg, ATGP2129-500 µg, ATGP2129-1 mg, ATGP2129-10, ATGP2129-20, ATGP2129-50, ATGP2129-100, ATGP2129-250, ATGP2129-500, ATGP2129-1

References & Citations

Kim N, Takami M, et al. (2002) . J Exp Med. 195 (2) :201-9.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Osteoporosis

NCBI Accession Number

NP_996554.1

Uniprot Accession Number

Q8IYS5

Species

Human

AA Sequence

DITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V