Recombinant human FBLIM1 protein
Filamin binding LIM protein 1, also known as FBLIM1, serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. This protein is implicated in cell shape modulation (spreading) and motility. It may participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. FBLIM1 promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. Recombinant human FBLIM1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Filamin binding LIM protein 1, CAL, FBLP-1, FBLP1, RP11-169K16.5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
43.1 kDa (396aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Tu Y., et al. (2003) Cell. 113:37-47; ; Takafuta T., et al. (2003) J. Biol. Chem. 278:12175-12181
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_060026
Uniprot Accession Number
Q8WUP2
Species
Human
AA Sequence
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